nsSNPAnalyzer is a tool to predict whether a nonsynonymous single nucleotide polymorphism (nsSNP) has a phenotypic effect.
It also provides additional information about the SNP to facilitate the interpretation of results, e.g., structural environment and multiple sequence alignment.
nsSNPAnalyzer uses information contained in the multiple sequence alignment and information contained in the 3D structure to make predictions.
To see an example: click on "Sample Data" then go to step "4" and click on "Run".
Sequence Data (protein sequence in fasta format)
OR Enter here:

SNP Data
OR Enter here:

Optional Data:
(nsSNPAnalyzer will automatically search for the homologous 3-D structure. You may also provide your own PDB file and chain. )
PDB file:
Chain: (If there is only one chain in the PDB file, please choose the character of "_")
Email Address:
(If you provide an email address here, you will receive the result in the email when the process finishes and you don't have to wait on line)